Open AccessX-linked recessive Kallmann syndrome: A case report
Author(s) -
Ping Zhang,
Jing-Yun Fu
Publication year - 2022
Publication title -
world journal of clinical cases
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v10.i25.8990
Subject(s) - kallmann syndrome , hypogonadotropic hypogonadism , medicine , luteinizing hormone , endocrinology , infertility , kisspeptin , gynecomastia , hypothalamic disease , gonadotropin , gonadotropin releasing hormone , anovulation , hormone , polycystic ovary , pregnancy , obesity , disease , biology , genetics , insulin resistance , covid-19 , infectious disease (medical specialty)
Kallmann syndrome (KS), also known as hypogonadotropic hypogonadism (HH) or olfactory-gonadal dysplasia, is a genetic condition in which the primary symptom is a failure to begin puberty or a failure to fully complete it. It occurs in both males and females and has the additional symptoms of hypogonadism and almost invariably infertility. The condition has a low prevalence that is estimated to be 1 in 4000 for male HH cases overall and 1:50000 for KS. It is three to five times more common in males than females. Whether this is a true sex imbalance or a reflection of how difficult KS/HH is to diagnose correctly in males vs females has yet to be fully established.