Open AccessPrognostic role of multiple abnormal genes in non-small-cell lung cancer
Author(s) -
Luda Yan,
Liu Yang,
Na Li,
Meng Wang,
Yanhua Zhang,
Wen Zhou,
Zhi-Qiong Yu,
Xiaochun Peng,
Jianfei Cai
Publication year - 2022
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v10.i22.7772
Subject(s) - medicine , pten , kras , oncology , lung cancer , hazard ratio , proportional hazards model , stk11 , multivariate analysis , survival analysis , cancer , colorectal cancer , biology , apoptosis , genetics , confidence interval , pi3k/akt/mtor pathway
Non-small-cell lung cancer (NSCLC) has the highest morbidity and mortality rates among all malignant tumor types. Although therapies targeting the mutated genes such as KRAS have been used in the clinic for many years, the prognosis remains poor. Therefore, it is necessary to further study the aberrant expression or mutation of non-target genes affecting the survival and prognosis.