Open AccessDetection of a novel panel of 24 genes with high frequencies of mutation in gastric cancer based on next-generation sequencing
Author(s) -
Hu Zeng,
Zichen Yang,
Yebei Qiu,
Shoaib Bashir,
Yin Li,
Meng Xu
Publication year - 2022
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v10.i15.4761
Subject(s) - kras , cancer , medicine , microsatellite instability , germline mutation , mutation , exome sequencing , gene , pten , genetics , targeted therapy , cdkn2a , cancer research , colorectal cancer , biology , microsatellite , allele , pi3k/akt/mtor pathway , apoptosis
Gastric cancer is a leading cause of cancer-related mortality worldwide. Many somatic mutations have been identified based on next-generation sequencing; they likely play a vital role in cancer treatment selection. However, next-generation sequencing has not been widely used to diagnose and treat gastric cancer in the clinic.