Open AccessGlycolytic and fatty acid oxidation genes affect the treatment and prognosis of liver cancer
Author(s) -
Jia-Yue Zou,
Yujie Huang,
Jun He,
Zhuqi Tang,
Lei Qin
Publication year - 2022
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v10.i15.4737
Subject(s) - glycolysis , hepatocellular carcinoma , cancer research , medicine , liver cancer , anaerobic glycolysis , cancer , transcriptome , biology , bioinformatics , gene , metabolism , genetics , gene expression
Metabolic reprogramming is a feature of tumour cells and is essential to support their rapid proliferation. The glycolytic activity of liver cancer cells is significantly higher than that of normal liver cells, and the rapidly proliferating tumour cells are powered by aerobic glycolysis. Lipid metabolism reprogramming enables tumour cells to meet their needs for highly proliferative growth and is an important driving force for the development of hepatocellular carcinoma (HCC).