Open AccessClinical and prognostic significance of expression of phosphoglycerate mutase family member 5 and Parkin in advanced colorectal cancer
Author(s) -
Chi Wu,
Mingliang Feng,
Taiwei Jiao,
Min Sun
Publication year - 2022
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v10.i14.4368
Subject(s) - parkin , mitophagy , phosphoglycerate mutase , immunohistochemistry , cancer research , medicine , colorectal cancer , cancer , pathology , biology , apoptosis , biochemistry , parkinson's disease , disease , glycolysis , autophagy , metabolism
Drugs targeting mitochondria can induce mitophagy and restrain proliferation in colorectal cancer (CRC) cells. Phosphoglycerate mutase family member 5 (PGAM5) activates serine/threonine PTEN-induced putative kinase 1/Parkin pathway-mediated mitophagy. However, there are few studies on the clinical and prognostic significance of expression of PGAM5 protein and mitophagy-related protein Parkin in patients.