Open AccessCorrelation between thrombopoietin and inflammatory factors, platelet indices, and thrombosis in patients with sepsis: A retrospective study
Author(s) -
Wanhua Xu,
Li-Chan Mo,
Maohua Shi,
Hui Rao,
Xiao-Yong Zhan,
Mo Yang
Publication year - 2022
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v10.i13.4072
Subject(s) - medicine , thrombopoietin , sepsis , platelet , white blood cell , thrombopoiesis , mean platelet volume , gastroenterology , thrombosis , hematology , von willebrand factor , immunology , odds ratio , megakaryocyte , stem cell , genetics , haematopoiesis , biology
Thrombopoietin (TPO) is a primary regulator of thrombopoiesis in physiological conditions. TPO, in combination with its specific cytokine receptor c-Mpl, drives platelet production by inducing the proliferation and differentiation of megakaryocytes. However, the role of TPO in sepsis is not well determined. The elevated levels of TPO are often accompanied by a decrease of platelet count (PLT) in systemic infected conditions, which is contrary to the view that TPO promotes platelet production under physiological conditions. In addition, whether TPO mediates organ damage in sepsis remains controversial.