Open AccessSplenic hamartoma: A case report and review of the literature
Author(s) -
Jongsung Sim,
Hye In Ahn,
Haegin Han,
Young Jin Jun,
Abdul Rehman,
Sang Ock Jang,
Kiseok Jang,
Seung Sam Paik
Publication year - 2013
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v1.i7.217
Subject(s) - medicine , pathology , hamartoma , cd31 , spleen , differential diagnosis , splenectomy , lesion , cd34 , abdominal mass , atypia , radiology , immunohistochemistry , stem cell , biology , genetics
Splenic hamartoma is a rare benign malformation, composed of an anomalous mixture of normal splenic elements, often found incidentally while working up other complaints or at autopsy. A splenic mass was incidentally found while evaluating the effects of a traffic accident in a 63-year-old woman. Abdominal computed tomography revealed a well-defined splenic mass with rim enhancement. The patient underwent splenectomy. The resected spleen contained a well-defined mass lesion measuring 3.5 cm × 3.0 cm. Microscopic examination revealed disorganized slit-like vascular channels lined by plump endothelial cells without atypia. The cells lining the vascular channels were positive for CD8, CD31, CD34 and vimentin. Endothelial cells that are positive for CD8 are a key feature that differentiates hamartoma from other vascular lesions of the spleen. Although this tumor is very rare, it must be included in the differential diagnosis of splenic mass-forming lesions.