Open AccessSynchronous rectal and esophageal cancer treated with chemotherapy followed by two-stage resection
Author(s) -
Setsuo Utsunomiya,
K. Uehara,
Tetsuya Kurimoto,
Ken Hirose,
Masahide Fukaya,
Yu Takahashi,
Yoshihiko Taguchi,
Keita Itatsu,
Masato Nagino
Publication year - 2013
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v1.i2.87
Subject(s) - medicine , oxaliplatin , esophageal cancer , colorectal cancer , esophagectomy , surgery , neoadjuvant therapy , cetuximab , folfox , stage (stratigraphy) , chemotherapy , regimen , cancer , breast cancer , paleontology , biology
We report a case of 61-year-old male who had synchronous advanced rectal cancer involving the urinary bladder massively associated with multiple liver metastases, and esophageal cancer successfully treated by neoadjuvant chemotherapy followed by two-stage resection. Although complete resection of each of the lesions was considered possible by performing anterior pelvic exenteration, liver resection, and esophagectomy, it might be impossible for the patient to endure the stress of all of these operative procedures at once. Therefore, we planned to perform staged treatment with prioritizing consideration. First, we instituted chemotherapy with the FOLFOX (oxaliplatin + fluorouracil + leucovorin) plus cetuximab regimen, which could adequately control both rectal and esophageal cancer. After 6 cycles of chemotherapy, high anterior resection combined with cystoprostatectomy and lateral segmentectomy plus partial hepatectomy was performed followed by staged esophagectomy with three-field lymph node dissection. It was possible to use oxaliplatin and cetuximab safely as neoadjuvant therapy not only for advanced rectal cancer but for esophageal cancer, and it was effective.