Open AccessZingerone Attenuates Pi-induced Vascular Calcification via AMPK-mediated TIMP4 Expression
Author(s) -
YoungJu Lim,
Hyeon-Young Min,
WonGu Jang
Publication year - 2021
Publication title -
journal of lipid and atherosclerosis
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2288-2561
pISSN - 2287-2892
DOI - 10.12997/jla.2021.10.1.62
Subject(s) - vascular smooth muscle , ampk , medicine , endocrinology , chemistry , calcification , biology , protein kinase a , phosphorylation , biochemistry , smooth muscle
Vascular calcification requires the differentiation of vascular smooth muscle cells (VSMCs) into osteoblast-like cells. This phenomenon can be enhanced by inflammation and oxidative stress. Zingerone is one of the active ingredients present in the ginger plant that has anti-inflammatory and antioxidant effects. Other functions include anti-obesity, anti-nausea effects. However, the functions of zingerone on vascular calcification has not yet been elucidated. This study investigated the effect of zingerone on vascular calcification and its molecular mechanism.