Open AccessAnti-malarial Drugs Reduce Vascular Smooth Muscle Cell Proliferation via Activation of AMPK and Inhibition of Smad3 Signaling
Author(s) -
Heejung Lee,
Jung-Hwa Han,
Sujin Kim,
Du-Hyong Cho,
ChangHoon Woo
Publication year - 2019
Publication title -
journal of lipid and atherosclerosis
Language(s) - English
Resource type - Journals
eISSN - 2288-2561
pISSN - 2287-2892
DOI - 10.12997/jla.2019.8.2.267
Subject(s) - neointima , vascular smooth muscle , ampk , cell growth , cyclic guanosine monophosphate , protein kinase a , pharmacology , phosphorylation , chemistry , medicine , endocrinology , microbiology and biotechnology , biology , restenosis , biochemistry , nitric oxide , smooth muscle , stent
The aim of this study was to investigate the effects of 2 anti-malarial drugs, chloroquine (CQ) and hydroxychloroquine (HCQ), on inhibition of vascular smooth muscle cell (VSMC) proliferation both in vivo and in vitro via Adenosine monophosphate-activated protein kinase (AMPK) activation.