Open AccessAnticuerpos postvacunales frente a SARS-CoV-2 en una cohorte de trabajadores de un hospital general
Author(s) -
Susana Sabater Vidal,
María Dolores Tirado-Balaguer,
Raquel Soria-Martín,
Alberto Arnedo-Pena,
Abel Gil-Galdón,
Ma Carmen Bellido-Cambrón,
Ma Rosario Moreno-Muñoz
Publication year - 2022
Publication title -
archivos de prevención de riesgos laborales
Language(s) - Spanish
Resource type - Journals
eISSN - 1578-2549
pISSN - 1138-9672
DOI - 10.12961/aprl.2022.25.04.03
Subject(s) - medicine , covid-19 , humanities , gynecology , art , disease , infectious disease (medical specialty)
The aim was to estimate the evolution of the levels of anti-SARS-CoV-2 antibodies, the associated factors, and the incidence of new infections during the follow-up period. Method: Prospective cohort study of a representative sample of workers at the General University Hospital of Castellon 8 months after receiving the second dose of Pfizer-BioNTech vaccine against SARS-CoV-2, by determining IgG-S, IgG-NP, follow-up and response to a questionnaire. The results were compared with those at the start of the cohort in February 2021. Multivariate linear regression and Poisson regression were used. Results: A total of 253 workers participated out of the 275 in the start of the cohort. All had detectable levels of IgG-S, median 691% AU/ml, decreasing by 93.3% compared with the first study. The decline of IgG-S increased with age and obesity; and decreased with a COVID-19 previous history, regular exercise, and in smokers. IgG-NP was positively associated with a history of COVID-19, taking vitamin D, and decreased from 4.4% to 1.2%. There were 4 new cases of COVID-19 in the cohort, with and incidence rate of 1.7%. One death occurred in a participant with immunosuppressive treatment, only one case was asymptomatic and no reinfections occurred.