Open AccessPulmonary and central nervous system infiltration of chronic lymphocytic leukemia with concomitant diffuse large B-cell lymphoma: Case report and review of literature
Author(s) -
Saulo F. D. Batista,
Karina Vieira De Melo,
Patricia Regina Cavalcanti Barbosa Horn,
Vinícius da Cunha Lisboa,
Ana Sheila Cypriano,
Andrea Pires,
Marilza de Moura Ribeiro-Carvalho,
Fábio Santiago,
Maria Helena Faria Ornellas de Souza
Publication year - 2021
Publication title -
brazilian journal of health and biomedical sciences
Language(s) - English
Resource type - Journals
ISSN - 2674-8207
DOI - 10.12957/bjhbs.2020.59716
Subject(s) - medicine , concomitant , lymphoma , diffuse large b cell lymphoma , infiltration (hvac) , chronic lymphocytic leukemia , pathology , bronchoalveolar lavage , cerebrospinal fluid , respiratory failure , leukemia , lung , physics , thermodynamics
Diffuse large B-cell lymphoma (DLBCL) andchronic lymphoid leukemia (CLL) are lymphoproliferativediseases of B lymphocytes. Objective: To describe the concomitanceof diseases with pulmonary and CNS involvement.Clinical case: A 67-year-old patient with DLBCL and CLLobtained partial remission of the diseases after six cycles ofstandard combined chemotherapy. Relapse of CLL (del17p;TP53+) occurred after 22 months, becoming refractory to anew treatment. Monoclonal B lymphocyte infiltration wasfound in the cerebrospinal fluid and bronchoalveolar lavage,leading to death due to respiratory failure. Conclusion: Theunfavorable outcome shows a rare and serious complicationin the concomitance of these diseases.