Open AccessSPECIFIC MARKER OF NEURODEGENERATION IN OPTIC NEURITIS
Author(s) -
H. M. Kamilov,
М. С. Касимова,
Г. Х. Хамраева
Publication year - 2015
Publication title -
european medical, health and pharmaceutical journal
Language(s) - English
Resource type - Journals
eISSN - 1804-9702
pISSN - 1804-5804
DOI - 10.12955/emhpj.v8i1.541
Subject(s) - optic neuritis , medicine , atrophy , cerebrospinal fluid , stage (stratigraphy) , optic nerve , pathology , neurodegeneration , ophthalmology , multiple sclerosis , disease , immunology , paleontology , biology
Early diagnosis of optic neuritis (ON) is essential to prevent or limit the structural damage and permanent loss of visual function. The aim of this study was to estimate prognostic importance of the neuron-specific enolase (NSE) in blood serum and lachrymal fluid in optic neuritis. The clinical-diagnostic examination was performed on patients with optic neuritis, including optical coherence tomography (OCT) and Visually Evoked Potentials (VEP), MR – tractography, as well as analysis of NSE content in blood serum and in lachrymal fluid.Decreased level of NSE in lachrymal fluid in patients with acute stage of optic neuritis and increased level of NSE in patients with optic neuritis at the stage of transition into atrophy of optic nerve disc were detected. Comparative analysis demonstrated relatively high level of NSE in lachrymal fluid at transitional stage to atrophy as compared to acute phase.