Open AccessN-acetylcysteine potentiates the tumor cytotoxicity of cytokine-induced killer cells
Author(s) -
Pornpimon Ek-Eudomsuk,
Chonvara Chalermrujinanant,
Kitipong Soontrapa
Publication year - 2022
Publication title -
asian pacific journal of allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.405
H-Index - 33
ISSN - 0125-877X
DOI - 10.12932/ap-280921-1245
Subject(s) - cytokine induced killer cell , cytotoxic t cell , granzyme , granzyme b , population , cytotoxicity , perforin , biology , cytokine , cancer research , cytolysis , flow cytometry , cell culture , k562 cells , immunology , cd3 , t cell , immune system , cd8 , medicine , in vitro , biochemistry , leukemia , genetics , environmental health
Cytokine-induced killer (CIK) cells are an ex vivo expanded heterogeneous population of natural killer (NK)-like T cells that can exert potent MHC-unrestricted antitumor activity. A number of pre-clinical and clinical studies have demonstrated that CIK cells can serve as a safe and potent immunotherapy of malignant tumors. N-acetylcysteine (NAC) has been demonstrated to enhance the T-cell functions by increasing their proliferation and cytokine production.