Thrombosis with thrombocytopenia after the second ChAdOx1 nCoV-19 vaccination: A possible immunological mechanism independent of anti-platelet factor 4 antibody | Zendy

Noppacharn Uaprasert | Zendy; Ponlapat Rojnuckarin | Zendy

Open Access

Thrombosis with thrombocytopenia after the second ChAdOx1 nCoV-19 vaccination: A possible immunological mechanism independent of anti-platelet factor 4 antibody

Author(s) -

Noppacharn Uaprasert,

Ponlapat Rojnuckarin

Publication year - 2022

Publication title -

asian pacific journal of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.405

H-Index - 33

ISSN - 0125-877X

DOI - 10.12932/ap-101121-1271

Subject(s) - platelet factor 4 , medicine , platelet , antibody , immunology , thrombosis , vaccination , pulmonary embolism , platelet activation

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a distinctive syndrome characterized by unusual site thrombosis accompanied by thrombocytopenia following adenoviral vector vaccines against severe acute respiratory syndrome coronavirus 2. Platelet-activating anti-platelet factor 4-dependent antibodies (anti-PF4 Abs) have been identified as pathogenic antibodies in almost all patients.

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