Open AccessInternalization of cell-derived microparticles triggers endothelial pro-inflammatory responses
Author(s) -
Phatchanat Klaihmon,
Archrob Khuhapinant,
Wasinee Kheansaard,
Kovit Pattanapanyasat
Publication year - 2021
Publication title -
asian pacific journal of allergy and immunology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.405
H-Index - 33
ISSN - 0125-877X
DOI - 10.12932/ap-040920-0952
Subject(s) - umbilical vein , thalassemia , immunology , secretion , medicine , endothelial stem cell , interleukin 8 , endothelial activation , internalization , inflammation , biology , in vitro , receptor , biochemistry
Increased numbers of circulating microparticles (MPs) have long been documented in thalassemia and are considered as a contributing factor in developing the thromboembolic events (TEEs), which are associated with endothelial dysfunction. Indeed, the cellular and molecular mechanisms by which MPs and endothelial cells interact and their consequences remain poorly investigated.