Use of Midodrine in Heart Failure: Two Case Reports and a Review of the Literature | Zendy

Adnan Hajjiah | Zendy; Ossama Maadarani | Zendy; Zouheir Bitar | Zendy; Boutros Hanna | Zendy; Ragab Desouky Elshabasy | Zendy; Mohamed M. Abdelfatah | Zendy; Mohammad Gohar | Zendy

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Use of Midodrine in Heart Failure: Two Case Reports and a Review of the Literature

Author(s) -

Adnan Hajjiah,

Ossama Maadarani,

Zouheir Bitar,

Boutros Hanna,

Ragab Desouky Elshabasy,

Mohamed M. Abdelfatah,

Mohammad Gohar

Publication year - 2022

Publication title -

european journal of case reports in internal medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.125

H-Index - 1

ISSN - 2284-2594

DOI - 10.12890/2022_003246

Subject(s) - midodrine , medicine , orthostatic vital signs , heart failure , ejection fraction , guideline , blood pressure , anesthesia , heart rate , hemodynamics , clinical trial , cardiology , pathology

Hypotension in patients with heart failure is much more frequent in daily clinical practice than the 10–15% reported in clinical trials. In patients with heart failure with reduced ejection fraction (HFrEF), hypotension frequently limits the initiation and up-titration of guideline-directed medical therapy (GDMT). Midodrine is a peripheral alpha-1 agonist and a vasopressor anti-hypotensive agent approved for the treatment of orthostatic hypotension. We describe two cases where midodrine was prescribed in patients with HFrEF and hypotension.

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