Open AccessUse of Midodrine in Heart Failure: Two Case Reports and a Review of the Literature
Author(s) -
Adnan Hajjiah,
Ossama Maadarani,
Zouheir Bitar,
Boutros Hanna,
Ragab Desouky Elshabasy,
Mohamed M. Abdelfatah,
Mohammad Gohar
Publication year - 2022
Publication title -
european journal of case reports in internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2284-2594
DOI - 10.12890/2022_003246
Subject(s) - midodrine , medicine , orthostatic vital signs , heart failure , ejection fraction , guideline , blood pressure , anesthesia , heart rate , hemodynamics , clinical trial , cardiology , pathology
Hypotension in patients with heart failure is much more frequent in daily clinical practice than the 10–15% reported in clinical trials. In patients with heart failure with reduced ejection fraction (HFrEF), hypotension frequently limits the initiation and up-titration of guideline-directed medical therapy (GDMT). Midodrine is a peripheral alpha-1 agonist and a vasopressor anti-hypotensive agent approved for the treatment of orthostatic hypotension. We describe two cases where midodrine was prescribed in patients with HFrEF and hypotension.