Open AccessA Severe Case of Molluscum Contagiosum Immune Reconstitution Inflammatory Syndrome in a Patient with Human Immunodeficiency Virus
Author(s) -
Nida Siddiqui,
Brett Stephen Mansfield,
Nine-Paula Olmesdahl,
Peter Swart,
Jeremy Nel
Publication year - 2022
Publication title -
european journal of case reports in internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2284-2594
DOI - 10.12890/2022_003115
Subject(s) - immune reconstitution inflammatory syndrome , medicine , molluscum contagiosum , immune system , immunology , disease , immunity , refractory (planetary science) , virus , human immunodeficiency virus (hiv) , antiretroviral therapy , virology , viral load , pathology , biology , astrobiology
Paradoxical immune reconstitution inflammatory syndrome (IRIS) in human immunodeficiency virus (HIV)-positive patients initiating antiretroviral treatment (ART) is caused by restored immunity to specific antigens, resulting in worsening of a pre-existing infection. Molluscum contagiosum (MC) is commonly noted in HIV-positive individuals but ART alone is usually sufficient to bring about resolution. We present a rare case of severe MC-IRIS that worsened despite immune reconstitution.