A Severe Case of Molluscum Contagiosum Immune Reconstitution Inflammatory Syndrome in a Patient with Human Immunodeficiency Virus | Zendy

Nida Siddiqui | Zendy; Brett S. Mansfield | Zendy; Nine-Paula Olmesdahl | Zendy; Peter J. Swart | Zendy; Jeremy Nel | Zendy

Open Access

A Severe Case of Molluscum Contagiosum Immune Reconstitution Inflammatory Syndrome in a Patient with Human Immunodeficiency Virus

Author(s) -

Nida Siddiqui,

Brett S. Mansfield,

Nine-Paula Olmesdahl,

Peter J. Swart,

Jeremy Nel

Publication year - 2022

Publication title -

european journal of case reports in internal medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.125

H-Index - 1

ISSN - 2284-2594

DOI - 10.12890/2022_003115

Subject(s) - immune reconstitution inflammatory syndrome , medicine , molluscum contagiosum , immune system , immunology , disease , immunity , refractory (planetary science) , virus , human immunodeficiency virus (hiv) , antiretroviral therapy , virology , viral load , pathology , biology , astrobiology

Paradoxical immune reconstitution inflammatory syndrome (IRIS) in human immunodeficiency virus (HIV)-positive patients initiating antiretroviral treatment (ART) is caused by restored immunity to specific antigens, resulting in worsening of a pre-existing infection. Molluscum contagiosum (MC) is commonly noted in HIV-positive individuals but ART alone is usually sufficient to bring about resolution. We present a rare case of severe MC-IRIS that worsened despite immune reconstitution.

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