Open AccessPrimary Central Nervous System Lymphoma with Exclusive Leptomeningeal Involvement: The Diagnostic Challenge of a Rare Presentation of an Uncommon Disease
Author(s) -
Miguel C. Santos,
Tatiana Pires,
Ana Rodrigues,
Adriana Bandeira,
Ana Carolina Ferreira de Albuquerque,
Flávia Patrícia Sena Teixeira Santos,
Míriam Magalhães,
Maria Jesus Banza
Publication year - 2022
Publication title -
european journal of case reports in internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2284-2594
DOI - 10.12890/2022_003107
Subject(s) - medicine , leptomeninges , cerebrospinal fluid , lymphoma , presentation (obstetrics) , pathology , primary central nervous system lymphoma , differential diagnosis , disease , central nervous system , rare disease , radiology
Primary central nervous system lymphoma (PCNSL) is a rare and aggressive extra-nodal non-Hodgkin lymphoma (NHL). It must be confined to the brain, eyes, spinal cord or leptomeninges without systemic involvement at the time of diagnosis. Disease confined to the cerebrospinal fluid (CSF) is a rare form of presentation and poses a particular diagnostic challenge. We present the case of an 82-year-old man admitted to hospital because of an acute confusional state, later revealed to be due to PCNSL with exclusive leptomeningeal involvement. The diagnostic process was further impaired (or, perhaps, aided?) by the onset of a COVID-19 outbreak on the ward.
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