Open AccessMyasthenia Gravis Revealing Hodgkin’s Lymphoma
Author(s) -
Jaouad Yousfi,
F. Bensalek,
M. Zahlane,
L. Benjilali,
L. Essaadouni
Publication year - 2021
Publication title -
european journal of case reports in internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2284-2594
DOI - 10.12890/2021_2375
Subject(s) - myasthenia gravis , medicine , ptosis , lymphoma , weakness , muscle weakness , autoantibody , acetylcholine receptor , neuromuscular junction , neuromuscular disease , non hodgkin's lymphoma , pathology , antibody , disease , surgery , immunology , receptor , neuroscience , biology
Myasthenia gravis is a rare autoimmune disease caused by autoantibodies directed against the synapses of the neuromuscular junction. Patient and methods: We report the case of a young patient with myasthenia gravis associated with Hodgkin's lymphoma. Results: A 22-year-old patient presented with a 2-month history of severe weakness associated with muscle fatigability and intermittent ptosis without dysphonia or respiratory signs. Clinical examination revealed generalized myasthenia. The EMG did not show post-synaptic block, and anti-acetylcholine receptor antibodies were elevated at 3 nmol/l (normal ?0.3 nmol/l). CT of the thorax showed an anterior medial mass. Immunohistochemistry of the mass revealed mixed cellularity Hodgkin’s lymphoma. Conclusion: The association of lymphomas with myasthenia gravis has been rarely reported.