Myasthenia Gravis Revealing Hodgkin’s Lymphoma | Zendy

Jaouad Yousfi | Zendy; Fatimazahra Bensalek | Zendy; M. Zahlane | Zendy; L. Benjilali | Zendy; Lamiaâ Essaadouni | Zendy

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Myasthenia Gravis Revealing Hodgkin’s Lymphoma

Author(s) -

Jaouad Yousfi,

Fatimazahra Bensalek,

M. Zahlane,

L. Benjilali,

Lamiaâ Essaadouni

Publication year - 2021

Publication title -

european journal of case reports in internal medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.125

H-Index - 1

ISSN - 2284-2594

DOI - 10.12890/2021_2375

Subject(s) - myasthenia gravis , medicine , ptosis , lymphoma , weakness , muscle weakness , autoantibody , acetylcholine receptor , neuromuscular junction , neuromuscular disease , non hodgkin's lymphoma , pathology , antibody , disease , surgery , immunology , receptor , neuroscience , biology

Myasthenia gravis is a rare autoimmune disease caused by autoantibodies directed against the synapses of the neuromuscular junction. Patient and methods: We report the case of a young patient with myasthenia gravis associated with Hodgkin's lymphoma. Results: A 22-year-old patient presented with a 2-month history of severe weakness associated with muscle fatigability and intermittent ptosis without dysphonia or respiratory signs. Clinical examination revealed generalized myasthenia. The EMG did not show post-synaptic block, and anti-acetylcholine receptor antibodies were elevated at 3 nmol/l (normal ?0.3 nmol/l). CT of the thorax showed an anterior medial mass. Immunohistochemistry of the mass revealed mixed cellularity Hodgkin’s lymphoma. Conclusion: The association of lymphomas with myasthenia gravis has been rarely reported.

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