Open AccessA Case of Severe COVID-19 in a Patient with Good's Syndrome
Author(s) -
Maria Duarte,
Luciana Faria,
Catarina Patronillo,
Sónia da Costa Fernandes,
Vera Seara
Publication year - 2021
Publication title -
european journal of case reports in internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2284-2594
DOI - 10.12890/2021_002976
Subject(s) - medicine , thymectomy , thymoma , pediatrics , pneumonia , context (archaeology) , covid-19 , myasthenia gravis , disease , intensive care medicine , infectious disease (medical specialty) , surgery , paleontology , biology
Good’s syndrome is a rare adult-onset combined immunodeficiency. The association of hypogammaglobulinaemia with a history of recurrent infectious or autoimmune manifestations in a middle-aged patient with evidence of a mediastinal mass should lead to the clinical suspicion of Good’s syndrome. The mortality rate associated with infectious complications is high. Thus, although it is rare, the disease should be diagnosed early so that proper treatment can be started. Thymectomy and immunoglobulin replacement are the main therapeutic strategies. We describe the case of a patient with a history of thymoma and recurrent respiratory infections, with a late diagnosis of Good’s syndrome in the context of severe organizing pneumonia secondary to COVID-19.