Open AccessSevere Complication of Thiopurine Treatment in a Young Woman with Crohn’s Disease
Author(s) -
Michiel Pj Voet,
Tga Calon,
M M C Hendriks,
RM Schreuder
Publication year - 2021
Publication title -
european journal of case reports in internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2284-2594
DOI - 10.12890/2021_002350
Subject(s) - medicine , thiopurine methyltransferase , pancytopenia , complication , azathioprine , disease , cytomegalovirus infection , gastroenterology , surgery , immunology , bone marrow , virus , human cytomegalovirus
Case Description: TA 28-year old woman receiving thiopurine treatment for Crohn’s disease presented with a systemic primo cytomegalovirus (CMV) infection affecting the gut (colitis), liver (hepatitis), lungs (pneumonitis) and eyes (retinitis). Secondary to this systemic infection, she developed splenomegaly, pancytopenia and lymphadenopathy. Anti-viral treatment resulted in complete resolution of clinical, biochemical and radiological abnormalities within 6 weeks. Conclusion: Early recognition is crucial since CMV infection in a patient receiving thiopurine treatment may result in serious complications.