Open AccessMetamizole-Induced Type I Kounis Syndrome
Author(s) -
Catarina Lameiras,
Ana Corte-Real,
Ana Órfão,
Marta Mendes Lopes,
Maria Doria
Publication year - 2021
Publication title -
european journal of case reports in internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2284-2594
DOI - 10.12890/2021_002249
Subject(s) - medicine , kounis syndrome , metamizole , acute coronary syndrome , chest pain , myocardial infarction , cardiology , mexiletine , electrocardiography , tachycardia , anesthesia , analgesic
Kounis syndrome (KS) is defined as acute coronary syndrome (ACS) triggered by mast cell and platelet activation in the setting of allergic or anaphylactic insults. KS is a unique and complex cause of ACS and many cases may be missed due to its highly variable clinical manifestations. In this report, we present a case of KS type I triggered by metamizole in the absence of a previous history of allergy to this drug. Following the administration of metamizole, the patient developed generalized acute urticaria, chest pain and diaphoresis. Electrocardiography (ECG) showed ST-segment elevation suggestive of myocardial infarction complicated by ventricular tachycardia. No coronary disease was observed on coronary angiography. The cardiac manifestations of KS may be life-threatening, and so it is important to appropriately recognize and treat this condition.