Open AccessNeurofibromatosis Type 1 with Highly Active Relapsing-Remitting Multiple Sclerosis (RRMS)
Author(s) -
Silvia Ciotti,
Antonella Cometa,
Claudia De Carlo,
Giancarlo Martini,
Andrea Marona,
Laura Filippetti,
Diego Carducci,
Silvano Baratta,
Mauro Zampolini,
Francesco Corea
Publication year - 2021
Publication title -
european journal of case reports in internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2284-2594
DOI - 10.12890/2021_002190
Subject(s) - medicine , multiple sclerosis , neurofibromatosis , relapsing remitting , natalizumab , disease , pediatrics , dermatology , pathology , immunology
Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disease which confers an increased risk of malignant tumour development. Relapsing remitting multiple sclerosis (RRMS) is an inflammatory demyelinating disease of the central nervous system. The coexistence of multiple sclerosis and NF1 is rare but has been reported. Here, we describe the case of a 31-year-old man with NF1 and subacute walking problems with proximal pain in the lower limbs who was successfully treated with natalizumab.