Open AccessSkeletal Myopathy as the Initial Manifestation of Light Chain Multiple Myeloma
Author(s) -
Mohamed Reda Belkhribchia,
Sara Moukhlis,
Tarik Bentaoune,
N. Chourkani,
Mohamed Zaidani,
Mehdi Karkouri
Publication year - 2020
Publication title -
european journal of case reports in internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2284-2594
DOI - 10.12890/2020_002095
Subject(s) - immunoglobulin light chain , amyloidosis , multiple myeloma , medicine , myopathy , al amyloidosis , plasma cell dyscrasia , dyscrasia , pathology , context (archaeology) , monoclonal , paraproteinemias , plasma cell , immunology , antibody , monoclonal antibody , biology , paleontology
Monoclonal gammopathies due to plasma cell dyscrasias can cause various rare neuromuscular disorders. The peripheral nervous system is most commonly affected, while muscle diseases associated with monoclonal gammopathies are rare. Skeletal myopathy, as a manifestation in the context of multiple myeloma, is extremely uncommon and is usually the result of immunoglobulin light chain (AL) amyloidosis deposits in the muscles. Here we present an atypical case of a patient with generalized myopathy as the presenting manifestation of light chain multiple myeloma. Interestingly, muscle involvement in our case was not the consequence of AL amyloidosis deposits but rather due to non-amyloid light chain deposition disease associated with light chain multiple myeloma.