Open AccessHyperemesis Gravidarum: A Benign Condition of Pregnancy or a Challenging Metabolic Disorder?
Author(s) -
Matilda Florentin,
Ioannis Parthymos,
Aris P. Agouridis,
Georgé Liamis
Publication year - 2020
Publication title -
european journal of case reports in internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2284-2594
DOI - 10.12890/2020_001979
Subject(s) - hypochloremia , hyperemesis gravidarum , medicine , hypokalemia , hyponatremia , hyperuricemia , hypovolemia , metabolic disorder , metabolic alkalosis , pregnancy , creatinine , acute kidney injury , uric acid , endocrinology , gastroenterology , vomiting , biology , genetics
Hyperemesis gravidarum (HG) is a complication mainly of the first trimester of pregnancy, which sometimes leads to metabolic disorders such as hypovolemia and acute kidney injury (AKI). Herein, we present the case of a 25-year-old woman at week 10 of gestation who exhibited a constellation ofsevere abnormalities, namely AKI (serum creatinine 6.15 mg/dl), transaminasemia (serum aminotransferases >1,000 IU/l), alkalemia (arterial pH7.667), hyponatremia (serum sodium 117 mEq/l), hypochloremia (serum chloride 54 mEq/l),hypokalemia (serum potassium 2.2 mEq/l) and hyperuricemia (serum uric acid 20 mg/dl). Despite a thorough work-up, no other disorder was found apart from HG. All symptoms and metabolic abnormalities resolved with targeted administration of intravenous fluids. The differential diagnosis of these disorders and therapeutic challenges are discussed.