Open AccessPseudoacromegaly Associated with Non-Functioning Pituitary Adenoma
Author(s) -
Awatef Alotaibi,
Hassan Ahmad,
Moutaz Osman,
Khaled M. Alzahrani,
Faisal Alzahrani
Publication year - 2020
Publication title -
european journal of case reports in internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2284-2594
DOI - 10.12890/2020_001950
Subject(s) - acromegaly , gigantism , medicine , somatotropic cell , adenoma , growth hormone , endocrinology , hormone , pituitary adenoma , differential diagnosis , pathology
Acromegaly is characterized by excess skin and soft tissue growth due to increased growth hormone (GH) levels. Patients with similar physical findings but without somatotroph axis abnormalities are considered to have pseudoacromegaly. The list of pseudoacromegaly differential diagnoses is long. It may be caused by several congenital and acquired conditions and diagnosis can be challenging due to its rarity and occasional overlapping of some of these conditions. The presence of a pituitary tumour in such cases may lead to a misdiagnosis of acromegaly, and thus, biochemical evaluation is key. Here, we present a case of pseudoacromegaly with an acromegaloid phenotype, normal IGF levels, a supressed GH response to an oral glucose tolerance test, moderate insulin resistance and non-functioning pituitary microadenoma.