Open AccessPropofol-Induced Hepatitis
Author(s) -
Hanna Raisi,
Thomas Longerich,
Bernardo Moreira Assuncao,
Sebastian Mueller,
Peter Schirmacher,
HelmutKarl Seitz
Publication year - 2020
Publication title -
european journal of case reports in internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2284-2594
DOI - 10.12890/2020_001921
Subject(s) - medicine , propofol , hepatitis , toxic hepatitis , liver biopsy , jaundice , gastroenterology , liver injury , liver disease , necrosis , fibrosis , hepatitis a , biopsy , surgery
Objectives:To present a rare case of propofol-induced hepatitis. Materials and methods: A 59-year old man was referred to our department because of suspicion of toxic hepatitis after propofol anaesthesia for endoscopic colonoscopy. Results: The patient had jaundice, increased transaminases demonstrating liver necrosis, and liver stiffness of 18 kPa. Liver biopsy revealed bridging necrosis and initial post-collapse fibrosis. Following therapy with steroids and N-acetyl cysteine, the patient was discharged on the seventh day after admission in good general condition. Conclusion: Although propofol is considered safe, it can cause acute hepatitis, the seventh published case of which is reported here. Importantly, treatment with N-acetyl cysteine, a radical scavenger, but especially with steroids resulted in hepatic improvement.