Open AccessHigh-Titre ANA Positivity in NAFLD: An Uncommon Presentation of a Common Disease
Author(s) -
Asis Mitra,
Saswati Ray
Publication year - 2020
Publication title -
european journal of case reports in internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2284-2594
DOI - 10.12890/2020_001714
Subject(s) - anti nuclear antibody , medicine , titer , gastroenterology , fatty liver , liver biopsy , fibrosis , biopsy , disease , pathology , antibody , immunology , autoantibody
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and has emerged as a serious public health challenge. About 20% of NAFLD patients may have low titres ( 1:320) on presentation. After 3 months of diet, exercise and vitamin E supplementation,the patient was symptomatically better but her ANA titre had increased (>1:640). Her liver biopsy showed features of NAFLD with minimal fibrosis. High-titre ANA (>1:320) positivity is rare. Our patient showed a progressive rise in ANA titre from >1:320 to >1:640 within 3 months even though she was improving and histology showed minimal fibrosis.