Open AccessProtein digestibility and relevance to allergenicity.
Author(s) -
Gary A. Ban,
Tong Jen Fu,
Ian Kimber,
Dennis M. Hinton
Publication year - 2003
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.5812
Subject(s) - proteolysis , microbiology and biotechnology , digestion (alchemy) , agriculture , protein digestibility , proteolytic enzymes , biology , food science , biochemistry , chemistry , enzyme , ecology , chromatography
In January 2001 a Joint Food and Agriculture Organization of the United Nations/World Health Organization Expert Consultation Committee on Allergenicity of Foods Derived from Biotechnology published a report outlining in detail an approach for assessing the allergenic potential of novel proteins. One component of this decision tree is a determination of whether the protein of interest is resistant to proteolytic digestion. Although these (Italic)in vitro(/Italic) methodologies have been useful, the correlation between resistance to proteolysis and allergenic activity is not absolute. Two views and highlights of supporting research regarding the relationship of resistance to digestion and allergenicity are presented in this article.