Open AccessFolic Acid and Creatine as Therapeutic Approaches to Lower Blood Arsenic: A Randomized Controlled Trial
Author(s) -
Brandilyn A. Peters,
Megan N. Hall,
Xinhua Liu,
Faruque Parvez,
Tiffany R. Sanchez,
Alexander van Geen,
Jacob L. Mey,
Abu Baker Siddique,
Hasan Shahriar,
Mohammad Nasir Uddin,
Tariqul Islam,
Olgica Balac,
Vesna Ilievski,
Pam FactorLitvak,
Joseph H. Graziano,
Mary V. Gamble
Publication year - 2015
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.1409396
Subject(s) - creatine , placebo , medicine , creatinine , population , randomized controlled trial , urine , physiology , gastroenterology , environmental health , pathology , alternative medicine
The World Health Organization estimates that > 140 million people worldwide are exposed to arsenic (As)-contaminated drinking water. As undergoes biologic methylation, which facilitates renal As elimination. In folate-deficient individuals, this process is augmented by folic acid (FA) supplementation, thereby lowering blood As (bAs). Creatinine concentrations in urine are a robust predictor of As methylation patterns. Although the reasons for this are unclear, creatine synthesis is a major consumer of methyl donors, and this synthesis is down-regulated by dietary/supplemental creatine.