Recruitment of Normal Stem Cells to an Oncogenic Phenotype by Noncontiguous Carcinogen-Transformed Epithelia Depends on the Transforming Carcinogen | Zendy

Yuanyuan Xu | Zendy; Erik J. Tokar | Zendy; Rachel J. Person | Zendy; Rubén Orihuela | Zendy; Ntube N.O. Ngalame | Zendy; Michael P. Waalkes | Zendy

Open Access

Recruitment of Normal Stem Cells to an Oncogenic Phenotype by Noncontiguous Carcinogen-Transformed Epithelia Depends on the Transforming Carcinogen

Author(s) -

Yuanyuan Xu,

Erik J. Tokar,

Rachel J. Person,

Rubén Orihuela,

Ntube N.O. Ngalame,

Michael P. Waalkes

Publication year - 2013

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1306714

Subject(s) - matrigel , cancer research , cancer stem cell , stem cell , biology , cell culture , wnt signaling pathway , neural stem cell , mesenchymal stem cell , microbiology and biotechnology , chemistry , signal transduction , genetics , angiogenesis

Cancer stem cells (CSCs) drive tumor initiation, progression, and metastasis. The microenvironment is critical to the fate of CSCs. We have found that a normal stem cell (NSC) line from human prostate (WPE-stem) is recruited into CSC-like cells by nearby, but noncontiguous, arsenic-transformed isogenic malignant epithelial cells (MECs).

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