Open AccessRecruitment of Normal Stem Cells to an Oncogenic Phenotype by Noncontiguous Carcinogen-Transformed Epithelia Depends on the Transforming Carcinogen
Author(s) -
Yuanyuan Xu,
Erik J. Tokar,
Rubén Orihuela,
Ntube N. O. Ngalame,
Michael P. Waalkes
Publication year - 2013
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.1306714
Subject(s) - matrigel , cancer research , cancer stem cell , stem cell , biology , cell culture , wnt signaling pathway , neural stem cell , mesenchymal stem cell , microbiology and biotechnology , chemistry , signal transduction , genetics , angiogenesis
Cancer stem cells (CSCs) drive tumor initiation, progression, and metastasis. The microenvironment is critical to the fate of CSCs. We have found that a normal stem cell (NSC) line from human prostate (WPE-stem) is recruited into CSC-like cells by nearby, but noncontiguous, arsenic-transformed isogenic malignant epithelial cells (MECs).