Open AccessComparison of Intake and Systemic Relative Effect Potencies of Dioxin-like Compounds in Female Mice after a Single Oral Dose
Author(s) -
Karin I. van Ede,
Patrik L. Andersson,
Konrad P.J. Gaisch,
Martin van den Berg,
Majorie B.M. van Duursen
Publication year - 2013
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.1206336
Subject(s) - congener , adipose tissue , toxic equivalency factor , polychlorinated dibenzofurans , chemistry , endocrinology , medicine , polychlorinated dibenzodioxins , toxicokinetics , cytochrome p450 , pharmacokinetics , persistent organic pollutant , physiology , environmental chemistry , metabolism , hydrocarbon , organic chemistry
Risk assessment for mixtures of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) is performed using the toxic equivalency factor (TEF) approach. These TEF values are derived mainly from relative effect potencies (REPs) linking an administered dose to an in vivo toxic or biological effect, resulting in "intake" TEFs. At present, there is insufficient data available to conclude that intake TEFs are also applicable for systemic concentrations (e.g., blood and tissues).