Open AccessRelationship between Polycyclic Aromatic Hydrocarbon–DNA Adducts, Environmental Tobacco Smoke, and Child Development in the World Trade Center Cohort
Author(s) -
Frederica P. Perera,
Deliang Tang,
Virginia Rauh,
Yi Hsuan Tu,
Wei Yann Tsai,
Mark Becker,
Janet L. Stein,
Jeffrey C. King,
Giuseppe Del Priore,
Sally Ann Lederman
Publication year - 2007
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.10144
Subject(s) - bayley scales of infant development , cotinine , cord blood , cohort , tobacco smoke , in utero , medicine , environmental health , pyrene , umbilical cord , polycyclic aromatic hydrocarbon , pregnancy , physiology , fetus , chemistry , nicotine , environmental chemistry , biology , cognition , genetics , immunology , psychomotor learning , psychiatry , organic chemistry
Polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (BaP), are air pollutants released by the World Trade Center (WTC) fires and urban combustion sources. BaP-DNA adducts provide a measure of PAH-specific genetic damage, which has been associated with increased risk of adverse birth outcomes and cancer. We previously reported that levels of BaP-DNA adducts in maternal and umbilical cord blood obtained at delivery were elevated among subjects who had resided within 1 mile of the WTC site during the month after 9/11; and that elevated blood adducts in combination with in utero exposure to environmental tobacco smoke (ETS) were significantly associated with decreased fetal growth.