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Repair of chronic tympanic membrane perforations with long‐term epidermal growth factor
Author(s) -
Dvorak Douglas W.,
Abbas Greg,
Ali Tatar,
Stevenson Sherman,
Welling D. Bradley
Publication year - 1995
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199512000-00007
Subject(s) - tympanic membrane perforation , chinchilla , medicine , epidermal growth factor , cholesteatoma , perforation , surgery , wound healing , heparin binding egf like growth factor , dosing , tympanoplasty , anatomy , receptor , materials science , metallurgy , punching
Chronic tympanic membrane (TM) perforation is a common problem worldwide. Recent reports have shown epidermal growth factor (EGF) to stimulate healing in approximately 80% of chronic TM perforations in chinchillas when applied in three doses over 1 week. The objective of this controlled study is to evaluate the efficacy of long‐term EGF in the closure of TM perforations. Chronic chinchilla TM perforations were treated with EGF for up to 6 weeks. One hundred percent (17 of 17) of treatment group perforations completely healed. However, two new findings with this long dosing scheme were reperforation on long‐term follow‐up and three TMs with cholesteatomas. It is likely that reperforation was due to a progressive thinning seen with prolonged EGF application. Long‐term EGF use is not recommended for the treatment of TM perforations because of possible wound healing impairment and possible cholesteatoma induction.