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A murine model for the immunotherapy of head and neck squamous cell carcinoma
Author(s) -
Hier M.P.,
Black M.J.,
Shenouda G.,
Sadeghi N.,
Karp S.E.
Publication year - 1995
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199510000-00013
Subject(s) - head and neck squamous cell carcinoma , head and neck , immunotherapy , basal cell , cancer research , medicine , oncology , head and neck cancer , cancer , surgery
A murine model for the immunotherapy of head and neck cancer was established. The AT‐84 tumor, a spontaneously arising oral squamous cell tumor of C3H mice, was evaluated for susceptibility to lymphokine‐activated killer (LAK) cells. In vitro chromium‐release assays demonstrated that AT‐84 is sensitive to LAK‐cell‐mediated killing. Furthermore, in vivo experiments employing a lung metastasis model demonstrated a 50% reduction in the number of metastases in LAK‐cell‐treated mice as compared with untreated controls (P 2 =.001). These experiments showed that AT‐84 is an appropriate model for the immunotherapy of head and neck cancer. This model should be invaluable for further study of the mechanisms involved in immune‐mediated therapy of head and neck cancer.