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Neuroendocrine neoplasms of the larynx
Author(s) -
Overholt Samuel Mark,
Donovan Donald T.,
Schwartz Mary R.,
Laucirica Rodolfo,
Green Linda K.,
Alford Bobby R.
Publication year - 1995
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199508000-00004
Subject(s) - larynx , computational biology , biology , anatomy
Neuroendocrine neoplasms of the larynx are a rare group of tumors that include carcinoid tumor, atypical carcinoid tumor, and small cell carcinoma. These neoplasms pose interesting diagnostic, prognostic, and therapeutic dilemmas, and they are, as a whole, aggressive tumors with a tendency for local and distant spread. The authors of this study examined six new cases of laryngeal neuroendocrine neoplasms. One case manifested itself as a primary atypical carcinoid tumor and caused a “carcinoid syndrome.” The remaining five cases were small cell carcinomas of the larynx. Histologic, immunocytochemical, DNA flow cytometric, and p 53 studies were performed on all cases. The expression of neuron‐specific enolase and chromogranin were the most useful markers in this group of tumors. Overexpression of p 53 protein was present in the majority of cases, including the atypical carcinoid tumor. The implications of these studies for diagnosis, classification, and treatment are discussed.