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Treatment of vocal fold granuloma using botulinum toxin type A
Author(s) -
Nasri Sina,
Sercarz Joel A.,
Mcalpin Tina,
Berke Gerald S.
Publication year - 1995
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199506000-00005
Subject(s) - fold (higher order function) , vocal folds , toxin , botulinum toxin , vocal fold paralysis , medicine , biology , microbiology and biotechnology , larynx , computer science , anatomy , anesthesia , surgery , paralysis , programming language
Contact granuloma of the vocal folds has been associated with abnormal use of the voice, and acid reflux may exacerbate the inflammatory process. Treatments have included voice therapy and antireflux measures. Surgical excision is considered in patients who do not respond to medical management. Localized injections of botulinum toxin type A (BOTOX®) have been effective in patients with disorders of muscular control in the head and neck. In this study, granulomas resolved in six patients who underwent injection of the affected vocal folds. Botulinum toxin type A is probably successful because it prevents forceful closure of the arytenoids during phonation and coughing. Localized injection of this neurotoxin is promising both as an initial treatment and as an alternative treatment in patients who do not respond to standard therapy or who are poor surgical candidates.