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Eosinophilic infiltration in advanced laryngeal squamous cell carcinoma
Author(s) -
Sassier Alfred M.,
Mcclatchey Kenneth D.,
Wolf Gregory T.,
Fisher Susan G.
Publication year - 1995
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199504000-00014
Subject(s) - medicine , stage (stratigraphy) , larynx , carcinoma , eosinophilia , chemotherapy , basal cell , prospective cohort study , oncology , head and neck , head and neck squamous cell carcinoma , eosinophilic , pathology , radiation therapy , head and neck cancer , surgery , biology , paleontology
Tumor‐associated tissue eosinophilia (TATE) has been related to prognosis in epithelial cancers, including cancers at several head and neck sites. This study prospectively examined 248 patients with stage in and IV laryngeal squamous cell carcinoma to determine prevalence and potential prognostic significance of TATE. Pretreatment tumor specimens were histopathologically evaluated. Presence and degree of TATE were analyzed with regard to other tumor characteristics, patient characteristics, and outcome criteria. Median follow‐up was 48 months. Eosinophilia was found in 22.5% of specimens and was not related to tumor site, stage, patient age or sex, or treatment modality. Overall and disease‐free survival rates and response to induction chemotherapy did not differ significantly with respect to TATE. This study represents the first long‐term, prospective evaluation of TATE and its prognostic significance in a single head and neck site. Contrary to the findings of earlier preliminary reports, our results suggest that TATE is not a clinical useful prognostic parameter in advanced laryngeal squamous cell carcinoma.