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Otoacoustic emissions: An approach for monitoring aminoglycoside‐induced ototoxicity
Author(s) -
Hotz M. A.,
Harris Frances P.,
Probst R.
Publication year - 1994
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199409000-00014
Subject(s) - ototoxicity , aminoglycoside , otoacoustic emission , audiology , hair cell , amikacin , medicine , inner ear , outer hair cells , cochlea , anesthesia , hearing loss , pharmacology , antibiotics , chemistry , chemotherapy , anatomy , biochemistry , cisplatin
Ototoxic drugs, such as aminoglycosides, affect outer hair cell integrity in the inner ear. Transiently evoked otoacoustic emission (TEOAE) characteristics are related to outer hair cell function and can be expected to reflect the influence of ototoxic agents. Transiently evoked otoacoustic emissions were measured during amikacin sulfate therapy in nine patients. The duration of treatment for individual patients ranged from 9 to 33 days. A reversible decrease of overall TEOAE level, occurring after a treatment period longer than 16 days, was found in the majority of patients. The monitoring of TEOAEs is proposed as a method for early identification and, as a result, prevention of aminoglycoside‐induced ototoxicity.