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Cochlear polyamines: Markers of otitis media‐induced cochlear damage
Author(s) -
Naguib Maged B.,
Hunter Robert E.,
Henley Charles M.
Publication year - 1994
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199408000-00015
Subject(s) - spiral ligament , inner ear , organ of corti , spermidine , otitis , spermine , cochlea , spiral ganglion , polyamine , guinea pig , chemistry , pathology , anatomy , medicine , biology , biochemistry , endocrinology , surgery , enzyme
High‐performance liquid chromatography (HPLC) set to the femtoliter sensitivity level was used to identify and quantify the polyamines spermidine and spermine as well as the diamine putrescine in the different tissues of the inner ears of guinea pigs with experimentally induced otitis media. The tissues examined were the lateral wall (stria vascularis and the spiral ligament), the organ of Corti, and the cochlear nerve. The difference in polyamine profile in the different tissues of the control noninfected guinea pigs suggests a relation to the particular function of each of these tissues. The difference in polyamine profile in infected different inner ear tissues compared to controls encourages the assumption that the polyamines may be involved in a repair process of the inner ear after injury and that they may be considered as biochemical markers for inner ear damage secondary to acute otitis media.