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Factors affecting survival of patients with tumors of the anterior skull base
Author(s) -
Mccaffrey Thomas V.,
Olsen Kerry D.,
Yohanan James M.,
Lewis Jean E.,
Ebersold Michael J.,
Piepgras David G.
Publication year - 1994
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199408000-00006
Subject(s) - esthesioneuroblastoma , medicine , skull , surgery , perioperative , craniofacial , frontal sinus , basal cell , sinus (botany) , nasal cavity , botany , psychiatry , genus , biology
Fifty‐four patients with primary neoplasms of the anterior skull base were treated by craniofacial resection with curative intent. The most common tumor was esthesioneuroblastoma (24), followed by squamous cell carcinoma (10). The overall 2‐year and 5‐year survivals were 75% and 49%, respectively. High‐grade tumors, grades 3 and 4, had a poorer prognosis. Tumor size, dural involvement, sphenoid sinus involvement, age, and sex had no significant influence on survival when examined by multivariate survival analysis. Sixteen complications were noted in the postoperative period. Cerebrospinal fluid leakage occurred in 2 patients and loss of frontal bone occurred in 4. There were no operative or perioperative deaths. Craniofacial resection permits surgical resection of the majority of anterior skull base tumors with acceptable morbidity.