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Immunoperoxidase study of the endolymphatic sac in meniere's disease
Author(s) -
Dornhoffer John L.,
Waner Milton,
Arenberg I. Kaufman,
Montague Donna
Publication year - 1993
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199309000-00014
Subject(s) - electrocochleography , endolymphatic sac , meniere's disease , endolymphatic hydrops , medicine , immunoperoxidase , pathology , immune system , disease , inner ear , antibody , hearing loss , immunology , audiology , anatomy , monoclonal antibody
A growing body of evidence suggests that some cases of Meniere's disease may be mediated by immune mechanisms. Because endolymphatic sac dysfunction is believed to be an underlying cause of Meniere's disease, this study used immunohistochemical techniques to demonstrate the presence of immune complex deposition in the sacs of patients with Meniere's disease. Positive immunoglobulin G (IgG) staining was noted in 10 of 23 sac biopsies from Meniere's patients, with 2 specimens showing perivascular deposition. Only 1 of 5 control specimens was only slightly positive for IgG. Clinical correlation showed a statistically significant increase in disease bilaterality ( P <.05), larger summating potential/ action potential (SP/AP) ratios with electrocochleography (ECoG), and a tendency toward worse hearing and more progressive disease among the immunopositive Meniere's patients. The results provided histological evidence of immune injury in the endolymphatic sacs of patients with Meniere's disease.