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Prognostic value of histopathological parameters in 51 supraglottic squamous cell carcinomas
Author(s) -
De Guzmán R. Barona,
Martorell M. A.,
Basterra J.,
Armengot M.,
AlvarezValdés R.,
Garin L.
Publication year - 1993
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199305000-00011
Subject(s) - medicine , histopathology , neck dissection , lymph node , laryngectomy , epidermoid carcinoma , radiation therapy , stage (stratigraphy) , dissection (medical) , lymph , basal cell , pathology , radiology , carcinoma , larynx , surgery , paleontology , biology
The prognosis for supraglottic squamous cell carcinomas is difficult to establish. A study of 19 histopathological parameters (14 from the primary tumor and 5 from the lymph node metastases) was undertaken in 51 supraglottic epidermoid carcinomas. All patients were subjected to supraglottic horizontal laryngectomy with bilateral functional neck dissection and postoperative radiotherapy. A discriminant analysis was performed to relate the different histopathological variables to 5‐year survival. Capsule rupture and the number of metastatic lymph nodes were the only two parameters significantly related to survival ( P <.01). Histopathology (in particular, lymph node metastases) proved more effective in predicting patient evolution than TNM staging.