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Localization of interleukin‐1 in human squamous carcinomas of the head and neck
Author(s) -
Ahn Jeffrey M.,
Huang ChengChun,
Cho Hyung T.
Publication year - 1993
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199305000-00009
Subject(s) - bone resorption , pathology , blot , head and neck , monoclonal antibody , interleukin , medicine , epidermoid carcinoma , cancer research , resorption , antibody , cytokine , carcinoma , immunology , biology , gene , surgery , biochemistry
Recent investigations revealed that interleukin‐1 can promote bone resorption by activating osteoclasts. The authors' immunocytochemical studies with monoclonal antibody against human interleukin‐1 localized interleukin‐1 at the bone resorption site of the squamous carcinomas as well as within the squamous carcinomas. In addition, Western blotting and dot blotting methods were used to isolate interleukin‐1 from the extracts of the squamous carcinomas in the head and neck. Finding interleukin‐1, a potent bone resorption–stimulating factor, in squamous carcinomas suggests that interleukin‐1 might play an important role in the extensive local bone destruction seen in the head and neck patients with squamous carcinomas.