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Squamous Cell Carcinoma in HIV‐Positive Patients Under Age 45
Author(s) -
Roland J. Thomas,
Rothstein Stephen G.,
Mittal Khushbakhat R.,
Perksy Mark S.
Publication year - 1993
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199305000-00005
Subject(s) - medicine , incidence (geometry) , larynx , radiation therapy , basal cell , head and neck , human papillomavirus , disease , carcinoma , human immunodeficiency virus (hiv) , oral cavity , surgery , oncology , dentistry , immunology , physics , optics
Eight patients 45 years of age and under (range, 29 to 45) with squamous cell carcinoma of the head and neck and infection with the human immunodeficiency virus are reported. Primary tumor sites include nasopharynx, oral cavity, oropharynx, and larynx. Probes for the human papillomavirus were positive in two of the patients. Therapy consisted of surgery followed by radiation therapy in five patients, surgery alone in one patient, and radiation therapy in the remaining two patients. Follow‐up ranged up to 2 years and revealed four deaths, three patients alive without disease, and one patient recently posttreatment with residual disease. The significance of the presence of the human papillomavirus in these individuals remains to be determined. The incidence of squamous cell carcinoma of the head and neck under age 45 is low, and whether there may be a higher incidence in HIV‐positive patients cannot be determined from this small series.