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Aberrant expression of epidermal growth factor receptor in aural cholesteatoma
Author(s) -
Bujia J.,
Holly A.,
Schilling V.,
Negri B.,
Pitzke P.,
Schulz P.
Publication year - 1993
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199303000-00015
Subject(s) - cholesteatoma , epithelium , epidermis (zoology) , biology , epidermal growth factor , basal (medicine) , apocrine , receptor , epidermal growth factor receptor , hair follicle , pathology , microbiology and biotechnology , endocrinology , anatomy , medicine , genetics , radiology , insulin
A monoclonal antibody recognizing an epitope of the external domain of the human epidermal growth factor (EGF) receptor was used in an alkaline phosphatase‐antialkaline phosphatase (APAAP) technique to compare the distribution of this protein in normal human skin and aural cholesteatoma. EGF receptors appear to be highly expressed on the basal layer of the epidermis, in hair follicle apocrine sweat glands, and in the capillary system of normal skin. Cholesteatoma epithelium showed increased positive reactions in the suprabasal layers. A heterogeneity in the expression was found in different parts of the cholesteatoma. These results suggest the presence of an aberrant regulation and persistence of EGF receptors in cholesteatoma and confirm the hyperproliferative character of the cholesteatoma epithelium.