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Nonwound infections following head and neck oncologic surgery
Author(s) -
Weber Randal S.,
Hankins Patti,
Rosenbaum Beverly,
Raad Issam
Publication year - 1993
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199301000-00006
Subject(s) - medicine , head and neck , head and neck cancer , general surgery , oncologic surgery , surgery , radiation therapy
Little information exists regarding the comorbidity of postoperative nonwound infections (NWIs) in patients with head and neck cancer. Prospectively, 225 patients were randomized in a double‐blind fashion to receive either clindamycin or ampicillin sodium/sulbactam sodium for prevention of postoperative wound infection. Of the 113 patients receiving clindamycin, 14 developed nonwound infections, compared with 10 of 112 patients receiving ampicillin/sulbactam. A single site of nonwound infection occurred in 21 patients, and 2 sites occurred in 3 patients. The majority of infections were pulmonary (22), followed by urinary tract (3), septic phlebitis (1), and acute sinusitis (1). Gram‐negative organisms were isolated more frequently among patients on clindamycin (18) versus ampicillin/sulbactam (6) ( P = .014). Risk factors for pulmonary nonwound infection included: longer surgery, a greater than 70 packs per year smoking history, blood transfusion, and hypoalbuminemia ( P < .05). Nonwound infections produce significant postoperative morbidity and the predominance of gram‐negative organisms isolated from these infections has therapeutic implications.