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Monocyte Tumor Necrosis Factor Production in Head and Neck Squamous Cell Carcinoma
Author(s) -
Gallo Oreste,
Pinto Stefania,
Boccuzzi Simone,
Dilaghi Maurizio,
Gallina Ezio,
Attanasio Monica,
Gori Anna Maria,
Martini Francesca,
Abbate Rosanna
Publication year - 1992
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199204000-00014
Subject(s) - medicine , head and neck squamous cell carcinoma , tumor necrosis factor alpha , monocyte , peripheral blood mononuclear cell , head and neck cancer , cancer , oncology , stage (stratigraphy) , pathology , cancer research , in vitro , biology , paleontology , biochemistry
Changes in monocyte and macrophage function have been demonstrated in patients with head and neck squamous cell carcinoma. The purpose of this study was to evaluate tumor necrosis factor (TNT) production by activated monocytes from patients with head and neck squamous cell carcinoma and to evaluate its relation to cancer stage, weight loss, and performance status. Monocytes from patients (n = 10) and controls (n = 10) were isolated from peripheral blood mononuclear cells by plastic adherence and incubated with lipopolysaccharide (10 μg/mL). The TNF concentration of supernatants was assayed by TNFα‐specific immunoassay. The TNF production by monocytes from head and neck squamous cell carcinoma patients was significantly higher ( P <.001) than those of controls. No significant relationship was found to cancer stage, weight loss, and performance status. These findings indicate that, in head and neck squamous cell carcinoma patients, an increased TNF production by activated monocytes takes place which does not correlate with cancer stage, cancer‐related weight loss, and performance status.