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Treatment of oromandibular dystonia with botulinum toxin
Author(s) -
Hermanowicz Neal,
Truong Daniel D.
Publication year - 1991
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199111000-00010
Subject(s) - botulinum toxin , medicine , dysphagia , dystonia , focal dystonia , weakness , neuromuscular junction , clostridium botulinum , anesthesia , surgery , toxin , psychology , biochemistry , chemistry , neuroscience , psychiatry
Botulinum toxin produces muscle weakness by inhibition of acetylcholine release at the neuromuscular junction. The toxin has been used successfully for symptomatic treatment of focal dystonias. Our experience in the use of botulinum toxin for the treatment of oromandibular dystonia in five patients is reported. Improvement following treatment was reported as marked by 1 patient, moderate by 1 patient, and mild by 3 patients. Similar improvement was noted by the examiners. One patient with mild cosmetic improvement developed significant dysphagia requiring feeding by a nasogastric tube for a 3‐month period.